The classification criteria for both SLE and antiphospholipid syndrome (APS) have been updated, and up to 19 different subsets of neuropsychiatric lupus have been defined. New epidemiological data show that the incidence of new cases and the survival of patients 2020-08-03 Systemic lupus erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskeletal, renal, neuropsychiatric, hematologic, cardiovascular, pulmonary, and 2003-07-01 2009-03-01 2020-02-18 2012-06-25 2021-04-02 Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, with multisystemic involvement. The disease has several phenotypes, with varying clinical presentations in patients ranging from mild mucocutaneous manifestations to multiorgan and severe central nervous system involvement. Several ….
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Hymes SR, Jordon RE, Arnett FC. Lupus erythematosus represents a wide spectrum of diseases. Within this heterogeneity, however, several clinically relevant subsets have been found that may unite differing aspects of the disease and that may have pathogenic implications for the problem as a whole. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the aberrant production of a broad and heterogenous group of autoantibodies. PubMed PMID: 27730061; PubMed Central PMCID: PMC5038126. 12: Drehmer MN, Andrade D, Pereira IA, Marrero AR, Muniz YC, de Souza IR, Löfgren SE. Estrogen receptor alpha gene (ESR1) polymorphism can contribute to clinical findings in systemic lupus erythematosus patients. Lupus. 2016 Sep 27.
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by heterogeneous clinical manifestations involving virtually the entire body. The pain in SLE can have different causes.
Systemic lupus erythematosus is an autoimmune multi-system disease of uncertain aetiology with highly variable clinical manifestations. Women of child-bearing age are most often affected; however, ≈10–20% of cases occur in older patients. Elderly-onset lupus has been defined in various studies as onset of lupus after age 50–65 years.
Systemic lupus erythematosus develops in approximately one-quarter of patients with discoid lupus erythematosus within months to decades of the diagnosis of skin disease. Discoid lupus erythematosus may leave permanent scars, even when the active disease has responded to treatment. Who gets bullous systemic lupus erythematosus? The incidence of bullous SLE was estimated to be 0.22 and 0.26 cases per million per year in France and Singapore. In a large cohort of sera taken from patients with immunobullous disorders, 1–2% were identified as bullous SLE [1,2]. 2015-03-31 · Systemic lupus erythematosus (SLE) is a complex, autoimmune disorder that can have debilitating effects on various organs, including the kidneys. Here, Mohan and Putterman discuss the genetic Systemic lupus erythematosus is an autoimmune connective-tissue disorder with a wide range of clinical features, which predominantly affects women, especially from certain ethnic groups.
Abstract Discoid lupus erythematosus is a chronic dermatological disease that can lead to scarring, hair loss, and hyperpigmentation changes in skin if it is not treated early and promptly. It has a prolonged course and can have a considerable effect on quality of life. Early recognition and treatment improves the prognosis.
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1. Adv Nephrol Necker Hosp. 1976;6:63-77. Lupus erythematosus.
The pharmacological management of systemic lupus erythematosus (SLE) is challenging owing to its unpredictable clinical course, the variable organ system involvement and the lack of clear understanding of disease pathogenesis.
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Diagnosis is based on clinical assessment supported by investigations, including the finding of autoantibodies. Treatments range from antimalarial agents to corticosteroids and immunosuppressive agents.
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Discoid lupus erythematosus (DLE) is the most common chronic form of cutaneous lupus.It is characterised by persistent scaly, disk-like plaques on the scalp, face, and ears that may cause pigmentary changes, scarring and hair loss.. Lupus erythematosus (LE) is a group of diverse, persistent inflammatory autoimmune diseases and often affects the skin. Lupus, technically known as systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body.
Lupus 16 , 195–200 (2007). CAS PubMed Article PubMed Central Google Scholar 2007-01-18 · Resistance to Systemic Lupus Erythematosus. TLR5, the innate immune receptor for bacterial flagellin, maps to chromosome 1q41 and contains a common 1147C-T polymorphism that encodes a premature stop codon (R392X; 603031.0001) associated with increased susceptibility to Legionnaire disease (608556).
Skin disease is one of the most frequent clinical complaints of Systemic lupus erythematosus is a group of diseases that seem to become separate entities by etiology in the near future. Its pathogenesis remains elusive; Methods: A literature search was done in PubMed, accessed via the National Library of Medicine PubMed interface (http://www.ncbi.nlm.nih.gov/pubmed).